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Fifth, GLP-1RAs protect against cardiomyocyte apoptosis under diabetic conditions via activating the leucine zipper motif (APPL 1 )-AMPK-PPAR axis and the AMPK-TXNIP pathway [80, 161]

Despite having a higher rate of increase in the prevalence of diabetes over the past few years, the use of insulin in Asia has not increased to a large extent, and nearly half of the insulin users from Asia fail to achieve glycemic targets [1, 7]